Synapsin®: A Unique Blend in a Nasal Spray Delivery System for Neurological Health
Synapsin® is an innovative, patent-pending powder blend of ginsenoside Rg3 and nicotinamide riboside along with components to aid in solubilization and dispersion. These ingredients are designed to be used in the support of neurological health and cognitive health.? Synapsin® is commonly used in combination with methylcobalamin in formulations to support neuronal function and cognition.4
Traumatic brain injury (TBI) is a leading cause of injury, death and disability in the U.S.1,2 According to the CDC, approximately 2.4 million traumatic brain injuries were treated in U.S. emergency rooms in 2009, with an estimated 75% occurring as concussions. Of these, approximately 16.5% are associated with sports-related injury.2,3 A study of nearly 3,000 serious head trauma cases reported that 52% of survivors were moderately to severely disabled at one-year post accident.4
BRAIN DISORDERS: More than one million adults in the U.S. are diagnosed annually with a chronic brain disease or disorder, with Alzheimer’s disease being the most prevalent cause of adult-onset brain disorders.5 Research estimates that in the U.S., 35.8% of those 85 or older have moderate or severe memory impairment, and individuals 85 years and older are the fastest growing segment of the population.5
BRAIN FOG: Brain fog symptoms can vary from person to person based on mental and physiological condition(s). Brain fog can cause mild to chronic mental confusion, the inability to focus, and poor memory recall. It can also be associated with autoimmune dieases, lifestyle stress, cancer treatments, aging and more. Brain fog may also be commonly referred to as “brain fatigue” which may be linked to essential nutrient(s) deficiencies.
NEUROPLASTICITY: Neuroplasticity is the brain’s ability to reorganize and create neural connections. As we age, neuroplasticity can decline and an increase in neurodegeneration can occur, with oxidative stress as a major factor. Oxidative stress can be attributed to brain aging and memory impairment, and can also be hastened due to environmental and nutritional toxins.
Neurological Disorders & Diseases: Alzheimer’s, Dementia, Parkinson’s, Traumatic Brain Injury.
Brain Fog Symptoms: Due to lifestyle stress, autoimmune disorders, new mom “Jello Brain” and chronic fatigue.
Oxidative Stress: Supports neuroplasticity during aging process.
ABOUT METHYLCOBALAMIN: Naturally occurring coenzyme form of vitamin B12
Methylcobalamin circulates through the bloodstream and is a naturally-occurring coenzyme form of vitamin B12. The body needs B12 to convert homocysteine to methionine, protect DNA and RNA, support energy, protect nerve and brain cells, stimulate serotonin production, contribute to red blood cell formation, support immune function, and maintain a positive mood.
FREQUENTLY ASKED QUESTIONS
Does Synapsin® need to be refrigerated?
Yes. To maintain the stability of the nicotinamide riboside, Synapsin® needs to be refrigerated, and so does the final Synapsin® preparation.
Do Synapsin® preparations require a prescription?
Yes. Synapsin® formulations should only be compounded and dispensed as prescribed by a health care professional.
† Statements made are for educational purposes and have not been evaluated by the U.S. Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Faul, M., Xu, L., Wald, M. M., & Coronado, V. G. (2010). Traumatic brain injury in the United States: Emergency department visits, hospitalizations and deaths 2002–2006. Retrieved from https://www.cdc.gov/traumaticbraininjury/pdf/blue_book.pdf
Centers for Disease Control and Prevention (2010). QuickStats: Injury and Traumatic Brain Injury (TBI)-Related Death Rates, by Age Group — United States, 2006. Morbidity and Mortality Weekly Report, 59(10), 303. Retrieved from https://www.cdc.gov/mmwr/PDF/wk/mm5910.pdf
Centers for Disease Control and Prevention. (1999). Report to Congress: Traumatic brain injury in the United States. Retrieved from https://www.cdc.gov/traumaticbraininjury/pubs/tbi_report_to_ congress.html#
Thornhill, S., Teasdale, G. M., Murray, G. D., McEwen, J., Roy, C. W., & Penny, K. I. Disability in young people and adults one year after head injury: Prospective cohort study. The BMJ, 320, 1631–1635. https://doi.org/10.1136/bmj.320.7250.1631
Federal Interagency Forum on Aging-Related Statistics. (2000). Older Americans 2000: Key Indicators of Well-Being. Retreived from https://agingstats.gov/docs/PastReports/2000/OA2000.pdf
Joo, S. S., Yoo, Y. M., Ahn, B. W., Nam, S. Y., Kim, Y. B., Hwang, K. W., & Lee, D. I. (2008). Prevention of inflammation-mediated neurotoxicity by Rg3 and its role in microglial activation. Biological and Pharmaceutical Bulletin, 31(7), 1392-1396. http://doi.org/10.1248/bpb.31.1392
Bao, H. Y., Zhang, J., Yeo, S. J., Myung, C. S., Kim, H. M., Kim, J. M., . . . Kang, J. S. (2005). Memory enhancing and neuroprotective effects of selected ginsenosides. Archives of Pharmacal Research, 28(3), 335-342.
Mannaa, F., Abdel-Wahhab, M. A., Ahmed, H. H., & Park, M. H. (2006). Protective role of Panax ginseng extract standardized with ginsenoside Rg3 against acrylamide-induced neurotoxicity in rats. Journal of Applied Toxicology, 26(3), 198-206. https://doi.org/10.1002/jat.1128
Bieganowski, P., & Brenner, C. (2004). Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans. Cell, 117(4), 495-502. Retrieved from http://www.cell.com/cell/pdf/S0092-8674(04)00416-7.pdf
Belenky, P., Bogan, K. L., & Brenner, C. (2007). NAD+ metabolism in health and disease. Trends in Biochemical Sciences, 32(1), 12-19. http://dx.doi.org/10.1016/j.tibs.2006.11.006
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