Synapsin Neuro Health Fusion Pharmacy

Synapsin –Nasal Spray Delivery System for Neurological Health

Synapsin® is an innovative, patent-pending powder blend of ginsenoside Rg3 and nicotinamide riboside, along with components to aid in solubilization and dispersion. These ingredients are designed to be used in the support of neurological and cognitive health.† Synapsin® is commonly used in combination with methylcobalamin in formulations that support neuronal function and cognition.4

SYNAPSIN® FOR TBI & BRAIN HEALTH

Traumatic Brain Injury (TBI) is a leading cause of injury, death, and disability in the U.S.1,2 According to the Center for Disease Control (CDC), approximately 2.4 million traumatic brain injuries were treated in U.S. emergency rooms in 2009, with an estimated 75% occurring as concussions. Of these, approximately 16.5% are associated with a sports-related injury.2,3 A study of nearly 3,000 serious head trauma cases reported that 52% of survivors were moderately to severely disabled at one-year post accident.4

BRAIN DISORDERS

More than one million adults in the U.S. are diagnosed annually with chronic brain disease or disorder, with Alzheimer’s disease being the most prevalent cause of adult-onset brain disorders.5 Research estimates that in the U.S., 35.8% of those 85 or older have moderate or severe memory impairment, and individuals 85 years and older are the fastest growing segment of the population.5

BRAIN FOG

Brain fog symptoms can vary from person to person based on mental and physiological condition(s). Brain fog can cause mild to chronic mental confusion, the inability to focus, and poor memory recall. It can also be associated with autoimmune diseases, lifestyle stress, cancer treatments, aging and more. Brain fog may also be commonly referred to as “brain fatigue” which may be linked to essential nutrient(s) deficiencies.

NEUROPLASTICITY

Neuroplasticity is the brain’s ability to reorganize and create neural connections. As we age, neuroplasticity can decline and an increase in neurodegeneration can occur, with oxidative stress as a major factor. Oxidative stress can be attributed to brain aging and memory impairment and can also be hastened due to environmental and nutritional toxins.

Learn About Active Ingredients

GINSENOSIDE Rg3: Supports Neuroprotection 

Rg3 is one of several triterpene saponins (ginsenosides) found in the plant genus Panax, including Panax ginseng (Asian ginseng) and Panax quinquefolius (American ginseng). Laboratory studies report that Rg3 extracted from Panax ginseng supports neuroprotection, helping to support healthy microglial activity and healthy neuronal function.12,13,14†

NICOTINAMIDE RIBOSIDE: Supports neuronal NAD+ synthesis without inhibiting sirtuins
Nicotinamide riboside (NR) is a form of vitamin B3 found in cow’s milk.15 Laboratory studies report administration of nicotinamide riboside supports healthy levels of NAD+ in yeast and cultured human and mammalian cells. NR is reported to be incorporated into the cellular NAD+ pool via the action of nicotinamide riboside kinase (Nrk) pathway or via nicotinamide (Nam) salvage after conversion to Nam by phosphorolysis.15,16,17† Laboratory studies have also reported the supportive and neuroprotective role for NAD+.16† In laboratory studies, nicotinamide riboside supports neuronal NAD+ synthesis without inhibiting sirtuins, which are important regulators of metabolism and longevity.18,19†

 METHYLOCOBALAMIN: Naturally occurring coenzyme form of vitamin B12

Methylcobalamin circulates through the bloodstream and is a naturally occurring coenzyme form of vitamin B12. The body needs B12 to convert homocysteine to methionine, protect DNA and RNA, support energy, protect nerve and brain cells, stimulate serotonin production, contribute to red blood cell formation, support immune function, and maintain a positive mood. 

Does Synapsin® need to be refrigerated?
Yes. To maintain the stability of the nicotinamide riboside, Synapsin® needs to be refrigerated, and so does the final Synapsin® preparation.
Does Synapsin® require a prescription?
Yes. Synapsin® formulations should only be compounded and dispensed as prescribed by a health care professional.
How much is Synapsin®?
Pricing starts at $72.58. (Does not include shipping)
Can I modify the formula of my Synapsin®?
Yes! We can substitute Hydroxocoblamin in place of Methylcobalamin. Additional added ingredients can include Alpha GPC or NAD+ (Nicotinamide adenine dinucleotide).

NEUROLOGICAL DISORDERS

Alzheimer’s, Dementia, Parkinson’s, Traumatic Brain Injury.

BRAIN FOG SYMPTOMS

Due to lifestyle stress, autoimmune disorders, new mom “Jell-O Brain” and chronic fatigue.

OXIDATIVE STRESS

Supports neuroplasticity during aging process.

REFERENCES:

  1. Faul, M., Xu, L., Wald, M. M., & Coronado, V. G. (2010). Traumatic brain injury in the United States: Emergency department visits, hospitalizations and deaths 2002–2006. Retrieved from https://www.cdc.gov/traumaticbraininjury/pdf/blue_book.pdf
  2. Centers for Disease Control and Prevention (2010). QuickStats: Injury and Traumatic Brain Injury (TBI)-Related Death Rates, by Age Group — United States, 2006. Morbidity and Mortality Weekly Report, 59(10), 303. Retrieved from https://www.cdc.gov/mmwr/PDF/wk/mm5910.pdf
  3. Centers for Disease Control and Prevention. (1999). Report to Congress: Traumatic brain injury in the United States. Retrieved from https://www.cdc.gov/traumaticbraininjury/pubs/tbi_report_to_congress.html
  4. Thornhill, S., Teasdale, G. M., Murray, G. D., McEwen, J., Roy, C. W., & Penny, K. I. Disability in young people and adults one year after head injury: Prospective cohort study. The BMJ, 320, 1631–1635. https://doi.org/10.1136/bmj.320.7250.1631
  5. Federal Interagency Forum on Aging-Related Statistics. (2000). Older Americans 2000: Key Indicators of Well-Being. Retrieved from https://agingstats.gov/docs/PastReports/2000/OA2000.pdf
  6. Joo, S. S., Yoo, Y. M., Ahn, B. W., Nam, S. Y., Kim, Y. B., Hwang, K. W., & Lee, D. I. (2008). Prevention of inflammation-mediated neurotoxicity by Rg3 and its role in microglial activation. Biological and Pharmaceutical Bulletin, 31(7), 1392-1396. http://doi.org/10.1248/bpb.31.1392
  7. Bao, H. Y., Zhang, J., Yeo, S. J., Myung, C. S., Kim, H. M., Kim, J. M., . . . Kang, J. S. (2005). Memory enhancing and neuroprotective effects of selected ginsenosides. Archives of Pharmacal Research, 28(3), 335-342. https://www.ncbi.nlm.nih.gov/pubmed/15832823
  8. Mannaa, F., Abdel-Wahhab, M. A., Ahmed, H. H., & Park, M. H. (2006). Protective role of Panax ginseng extract standardized with ginsenoside Rg3 against acrylamide-induced neurotoxicity in rats. Journal of Applied Toxicology, 26(3), 198-206. https://doi.org/10.1002/jat.1128
  9. Bieganowski, P., & Brenner, C. (2004). Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans. Cell, 117(4), 495-502. Retrieved from http://www.cell.com/cell/pdf/S0092-8674(04)00416-7.pdf
  10. Belenky, P., Bogan, K. L., & Brenner, C. (2007). NAD+ metabolism in health and disease. Trends in Biochemical Sciences, 32(1), 12-19. http://dx.doi.org/10.1016/j.tibs.2006.11.006

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