*A PRESCRIPTION IS REQUIRED FOR THIS COMPOUND
Ketamine and Therapeutic Uses
What Is Ketamine?
Ketamine belongs to a class of drugs known as dissociative anesthetics. It is also known as Ketalar, Ketanest, and Ketaset.
Ketamine was first discovered in 1962, and was used as a battlefield anesthetic during the Vietnam War. Ketamine is a N-methyl-D-aspartate glutamate (NMDA) receptor antagonist. It is available in a nasal spray, a troche (mouth lozenge), mouth wash, and as a cream applied topically.
Ketamine induces a trance-like state while providing pain relief, sedation, and memory loss. Other uses include sedation in intensive care, treatment of pain, and depression.
Ketamine For Pain
Ketamine has been used medically as a topical pain cream ingredient for its ability to block N-methyl-D-aspartate (NMDA) receptors, which has been shown to help in decreasing pain perception, and decreasing sensation of pain.
- Pain caused from injury or degeneration
- Inflammation disorders
Ketamine can be combined with NSAIDs (nonsteroidal anti-inflammatory drugs), and other ingredients such as; cannabidiol, gabapentin, baclofen, diclofenac, and lidocaine.
Fusion Pharmacy can compound a personalized pain cream to meet the needs of any patient.
Ketamine Nasal Spray For Depression
Researchers began to examine the use of ketamine as a treatment for major depressive disorder (MDD) in the 2000s. Since then, ketamine has been shown to also help with drug treatment resistant depression, as well as depression combined with anxiety.
Nasal Spray Delivery Method
Because the nasal cavity is covered by a thin mucosa that is well vascularised, delivering medications through the nasal cavity is faster acting than going through the digestive process. It is important to use the medication as directed, and report any side-effects to your doctor and our pharmacists.
Ketamine Mouthwash For Side-Effects Related To Chemotherapy Treatment
Nearly 40% of patients receiving chemotherapy and radiation to treat their cancer can experience severe mucositis (inflammation of the tissue in the mouth).
Cancer treatment patients with severe mucositis are unable to eat, or drink. Sores in the mouth can also become so uncomfortable that they will either decrease their cancer treatment, or stop it completely.
Ketamine mouthwash has been shown to help with reducing pain, and in some cases reducing narcotic analgesics.
Self Guided Research:
There are several clinical studies that have looked at Ketamine as a treatment for pain, depression, bipolar disorder, post traumatic distress disorder and sleep.
References for these studies are listed below to help you with your self-guided research:
A double-blind, placebo-controlled trial of a topical treatment for chemotherapy-induced peripheral neuropathy: NCCTG trial N06CA. (https://pubmed.ncbi.nlm.nih.gov/20496177/
Analgesic effects of topical ketamine. (https://pubmed.ncbi.nlm.nih.gov/24847738/)
A Pilot study examining topical amitriptyline, ketamine, and a combination of both in the treatment of neuropathic pain. (https://pubmed.ncbi.nlm.nih.gov/12966259/)
Effective use of topical amitriptyline hydrochloride 2.5% and ketamine hydrochloride 0.5% for analgesia in refractory proctodynia. (https://pubmed.ncbi.nlm.nih.gov/19112806/)
Ketamine mouthwash for mucositis pain. (https://pubmed.ncbi.nlm.nih.gov/19708855/)
Ketamine as an analgesic: parenteral, oral, rectal, subcutaneous, transdermal and intranasal administration. (https://pubmed.ncbi.nlm.nih.gov/14640353/)
Mechanisms and treatment of neuropathic pain. (https://pubmed.ncbi.nlm.nih.gov/19708855/)
Transdermal Lidocaine and Ketamine for Neuropathic Pain: A Study of Effectiveness and Tolerability. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401865/)
Ketamine and depression: a narrative review. (https://pubmed.ncbi.nlm.nih.gov/31695324/)
Ketamine as treatment for depression. (https://pubmed.ncbi.nlm.nih.gov/29199810/)